Pro-Creatine E2 ethyl ester is creatine at the end stage of evolution. By bonding an ester to creatine, it has been given a lipophilic (fat penetrating) property meaning that any fluid retained will be in muscle cells, not under the skin.Creatine ethyl ester is the most absorbable form of creatine. The ethyl ester is a delivery system that bypasses the need for creatine transporters (as mentioned below) and is delivered directly into the muscle cells. Once the creatine ethyl ester enters the muscle, the ethyl ester is simply removed by the estrases leaving creatine in its salt form. This results in water being pulled inside the muscle. Pro Creatine E2 does not have to be cycled and can be used continuously.