Molybdenum

What is it?

Molybdenum is an essential trace mineral needed for the proper function of certain enzyme-dependent processes, including the metabolism of iron.

Preliminary evidence indicates that molybdenum, through its involvement in detoxifying sulphites, might reduce the risk of sulphite-reactive asthma attacks.¹ However, a physician should be involved in the evaluation and treatment of sulphite sensitivity.

Where is it found?

The amount of molybdenum in plant foods varies significantly and is dependent upon the mineral content of the soil. The best sources of this mineral are beans, dark green leafy vegetables, and grains. Hard tap water can also supply molybdenum to the diet. Molybdeum is also available as a supplement.

Molybdenum has been used in connection with the following condition (refer to the individual health concern for complete information):

Rating	Health Concerns
	Asthma
Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.

How much is usually taken?

No recommended dietary allowance (RDA) has been established for molybdenum. The estimated range recommended by the Food and Nutrition Board as safe and adequate is 75–250 mcg per day for adults.

Are there any side effects or interactions?

Molybdenum is needed to convert purine to uric acid, and excessive intake could, in rare cases, increase uric acid levels and potentially trigger gout. Molybdenum interferes with the absorption of copper; long-term supplementation with molybdenum could, in theory, result in copper deficiency. Molybdenum has been reported to cause psychosis in a patient taking 300 to 800 mcg per day for 18 days. This report is as yet unsubstantiated by any other human or animal research.²

At the time of writing, there were no well-known drug interactions with molybdenum.

References

1. Johnson JL, Wuebbens MM, Mandell R, et al. Molybdenum cofactor deficiency in a patient previously characterized as deficient in sulfite oxidase. Biochem Med Metabol Biol 1988;40:86–93.

2. Momcilovic B. A case report of acute human molybdenum toxicity from a dietary molybdenum supplement—a new member of the “Lucor metallicum” family. Arh Hig Rada Toksikol 1999;50:289–97.

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2005.